原標(biāo)題：短期接觸草花粉是否對肺功能和氣道炎癥有害？
背景：草花粉接觸與哮喘惡化的早期標(biāo)志如肺功能改變和氣道炎癥增加之間的聯(lián)系是有限的。我們在一個以群落為基礎(chǔ)的樣本中調(diào)查了短期草花粉接觸與肺功能和氣道炎癥之間的關(guān)系，以及這些關(guān)系是否受到正在哮喘、花粉熱、花粉過敏、年齡和其他環(huán)境因素的影響。
方法：數(shù)據(jù)的橫向和短期分析來自于墨爾本特異反應(yīng)性隊列研究（MACS）的參與者（n=936）。肺功能測定采用肺活量法。氣道炎癥通過呼出氣中一氧化氮（FeNO）和呼出冷凝液pH和氮氧化物（NOx）進行評估。每日花粉計數(shù)收集使用定容式孢子捕捉器。相關(guān)性用線性回歸分析。
結(jié)果：在較高的環(huán)境草花粉水平下接觸2天與較低的中期用力呼氣流量（FEF25%-75%）和FEV1/FVC比值有關(guān)，接觸3天的情況也是如此。接觸1天高濃度草花粉含量的增加與FeNO（4.35）的增加有關(guān)，接觸2天的情況也是如此。在哮喘、花粉熱和花粉過敏的成人中，花粉接觸更會導(dǎo)致多種不良結(jié)果。
結(jié)論：接觸后1-2天，會導(dǎo)致嗜酸性氣道炎癥，接觸后2-3天會引起氣道阻塞。患有哮喘、花粉熱和花粉過敏的成人可能有更高的風(fēng)險。


延伸閱讀
Allergy                                                   
[IF:6.771]
Is short-term exposure to grass pollen adversely associated with lung function and airway inflammation in the community?
DOI: 10.1111/all.14566
Abstract:
Background: The association between grass pollen exposure and early markers of asthma exacerbations such as lung function changes and increase in airway inflammation is limited. We investigated the associations between short-term grass pollen exposure and lung function and airway inflammation in a community-based sample, and whether any such associations were modified by current asthma, current hay fever, pollen sensitization, age, and other environmental factors.
Methods: Cross-sectional and short-term analyses of data from the Melbourne Atopy Cohort Study (MACS) participants (n = 936). Lung function was assessed using spirometry. Airway inflammation was assessed by fractional exhaled nitric oxide(FeNO) and exhaled breath condensate pH and nitrogen oxides (NOx). Daily pollen counts were collected using a volumetric spore trap. The associations were examined by linear regression.
Results: Higher ambient levels of grass pollen 2 days before (lag 2) were associated with lower mid-forced expiratory flow (FEF25%-75%) and FEV1/FVC ratio (Coef. [95%CI] = ?119 [?226, ?11] mL/s and ?1.0 [?3.0, ?0.03] %, respectively) and also 3 days before (lag 3). Increased levels of grass pollen a day before (lag 1) were associated with increased FeNO (4.35 [?0.1, 8.7] ppb) and also at lag 2. Adverse associations between pollen and multiple outcomes were greater in adults with current asthma, hay fever, and pollen sensitization.
Conclusion: Grass pollen exposure was associated with eosinophilic airway inflammation 1-2 days after exposure and airway obstruction 2-3 days after exposure. Adults and individuals with asthma, hay fever, and pollen sensitization may be at higher risk.
First Author:
Nur Sabrina Idrose
Correspondence:
Shyamali Dharmage, Centre of Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, 207 Bouverie St, Carlton, Vic. 3052, Australia.
All Authors:
Nur Sabrina Idrose, Rachel C. A. Tham, Caroline J. Lodge, Adrian J. Lowe, Dinh Bui, Jennifer L. Perret, Don Vicendese, Edward J. Newbigin, Mimi L. K. Tang, Fahad M. Aldakheel, Nilakshi T. Waidyatillake, Jo A. Douglass, Michael J. Abramson, Eugene Haydn Walters, Bircan Erbas, Shyamali C. Dharmage
2021-05-11 Article 
　　創(chuàng)建過敏性疾病的科研、科普知識交流平臺，為過敏患者提供專業(yè)診斷、治療、預(yù)防的共享平臺。