原標題:接受食物過敏口服免疫治療的8-12歲兒童的生活質量:兒童和父母的看法
——浙大迪迅 譯
背景:一般來說,父母都認為口服免疫療法(OIT)可以改善食物過敏兒童的生活質量(QOL),但是兒童自身對該療法的看法知之甚少。
方法:使用具有針對性的食物過敏生活質量問卷,對接受OIT的兒童(8-12歲)及其父母分別展開調查,時間節(jié)點設置為“開始進行牛奶、雞蛋、花生、芝麻或堅果的OIT時”、“最后一次給藥結束時”和“6個月后的隨訪時”。未接受OIT的食物過敏兒童作為對照組。比較分析兒童與其父母在QOL評分上的差異。
結果:103名接受OIT治療的兒童的調查問卷評分從OIT開始時的(中位數(IQR);4.8,3.8-5.7)到給藥結束時的(3.9,3-5.2),有明顯的改善(P<0.001)。觀察到在接受隨訪的56名兒童中表現出更顯著的改善,從OIT開始時的5.0(3.7-5.8)到隨訪時的3.1(1.8-5.0)(P<0.001)。相比之下,對照組兒童患者的調查問卷評分在兩個時間點從5.3(4.3-5.7)到4.8(3.6-6.0)有輕度的改善,但無顯著性差異(P=0.13)。在觀察期間,與對照組兒童患者的變化相比,OIT組從OIT開始到隨訪結束的調查問卷總評分有顯著的改善(P= 0.015)。在OIT的所有階段,父母的生活質量評分都比他們的孩子要好(開始4.0,3.2-5,P=0.004;結束給藥2.9,1.9-4.7,P=0.04;隨訪2.2,1.6-3.6,P=0.003)。
結論:與對照組相比,接受OIT的食物過敏兒童的QOL評分顯著改善。父母認為孩子生活質量改善的情況要優(yōu)于孩子自身的看法。
延伸閱讀
Allergy
[IF:6.771]
Quality of life of children aged 8-12 years undergoing food allergy oral immunotherapy: Child and parent perspective
DOI: 10.1111/all.14350
Abstract:
Background: Oral immunotherapy (OIT) for food allergy improves the quality of life (QOL) of children from parental perspective but little is known about the child perception.
Methods: The Food Allergy Quality of Life Questionnaire—Child Form (FAQLQ-CF) was administered to children aged 8-12 years, and the FAQLQ—Parent Form (FAQLQ-PF) was administered to their parents at the start of OIT for milk, egg, peanut, sesame, or tree nuts, at the end of up-dosing, and after 6 months of follow-up. Food-allergic children not undergoing OIT served as controls. Children QOL scores were compared to their parents.
Results: The total FAQLQ-CF score of 103 children undergoing OIT improved significantly from start of OIT (median (IQR); 4.8, 3.8-5.7) to end of up-dosing (3.9, 3-5.2) (P < .001). A greater improvement was noted in the 56 children who reached a followup visit, from 5.0 (3.7-5.8) at OIT start to 3.1 (1.8-5.0) on follow-up, (P < .001). In contrast, FAQLQ-CF scores of control patients improved mildly and nonsignificantly between the two time points from 5.3 (4.3-5.7) to 4.8 (3.6-6.0), (P = .13). The improvement in the total FAQLQ-CF scores from OIT start to follow-up was significantly greater compared to the change in control patients during observation (P = .015).
Parents reported better QOL scores compared to their children at all stages of OIT (start 4.0, 3.2-5, P = .004; end of up-dosing 2.9, 1.9-4.7, P = .04; follow-up 2.2, 1.6-3.6, P = .003).
Conclusion: QOL of food-allergic children undergoing OIT improves significantly compared to controls. Parents perceive QOL to be better than the perception of the children.
First Author:
Na'ama Epstein-Rigbi
Correspondence:
Na’ama Epstein-Rigbi, The Institute of Allergy, Asthma and Immunology, Shamir Medical Center (former Assaf Harofeh), Zerifin 71300, Israel.
All Authors:
Na'ama Epstein-Rigbi, Michael R. Goldberg, Michael B. Levy, Liat Nachshon, Arnon Elizur
2020-11-26 Article
創(chuàng)建過敏性疾病的科研、科普知識交流平臺,為過敏患者提供專業(yè)診斷、治療、預防的共享平臺。