原標(biāo)題：七個(gè)南歐國(guó)家花粉食物過敏綜合征的異質(zhì)性:多中心研究
背景：花粉食物過敏綜合征 (PFAS) 是一種經(jīng)常被漏診的疾病，其誘因、臨床表現(xiàn)和檢測(cè)結(jié)果多種多樣。這在具有廣泛花粉致敏性的地區(qū)尤其重要，例如南歐。
方法：作為@IT.2020 多中心研究的一部分，在七個(gè)國(guó)家招募了815名年齡在10-60歲之間的季節(jié)性過敏性鼻炎(SAR)患者。他們完成了關(guān)于SAR、合并癥、家族史和PFAS的問卷，并接受了皮膚點(diǎn)刺試驗(yàn) (SPT) 和血清IgE檢測(cè)。
結(jié)果：在815名患者中，167名（20.5%）報(bào)告了PFAS反應(yīng)。最常見的誘發(fā)食物是獼猴桃(58, 34.7%)、桃子(43, 25.7%)和甜瓜(26, 15.6%)。報(bào)告的反應(yīng)主要是局部的 (216/319, 67.7%)，發(fā)生在與誘發(fā)食物接觸的5分鐘內(nèi)(209/319, 65.5%)。相關(guān)特征包括對(duì)至少一種泛過敏原（profilin、PR-10 或 nsLTP）的IgE 陽(yáng)性（p = 0.007）、母系PFAS（OR：3.716，p = 0.026）和哮喘（OR：1.752，p = 0.073）。在中心之間，患病率（馬賽：7.5%與羅馬：41.4%，p < 0.001）和臨床特征的異質(zhì)性很明顯。柏樹的作用有限，只有1/22 SPT單一致敏患者報(bào)告食物不良反應(yīng)（p < 0.073）。
結(jié)論：PFAS是南歐SAR患者常見的合并癥。觀察到各中心PFAS患者臨床特征的顯著異質(zhì)性，可能與每個(gè)地理區(qū)域的不同花粉致敏模式有關(guān)。泛變應(yīng)原、母系PFAS和哮喘的IgE可能是PFAS相關(guān)的特征。


延伸閱讀
Allergy
Heterogeneity of pollen food allergy syndrome in seven Southern European countries: The @IT.2020 multicenter study
DOI: 10.1111/all.14742|
Abstract:
Background: Pollen food allergy syndrome (PFAS) is a frequently underdiagnosed disease due to diverse triggers, clinical presentations, and test results. This is especially relevant in geographic areas with a broad spectrum of pollen sensitization, such as Southern Europe.
Methods: As part of the @IT.2020 Multicenter Study, 815 patients with seasonal allergic rhinitis (SAR), aged 10–60 years, were recruited in seven countries. They completed questionnaires regarding SAR, comorbidities, family history, and PFAS, and underwent skin prick testing (SPT) and serum IgE testing.
Results: Of the 815 patients, 167 (20.5%) reported PFAS reactions. Most commonly, eliciting foods were kiwi (58, 34.7%), peach (43, 25.7%), and melon (26, 15.6%). Reported reactions were mostly local (216/319, 67.7%), occurring within 5 min of contact with elicitors (209/319, 65.5%). Associated characteristics included positive IgE to at least one panallergen (profilin, PR-10, or nsLTP) (p = 0.007), maternal PFAS (OR: 3.716, p = 0.026), and asthma (OR: 1.752, p = 0.073). Between centers, heterogeneity in prevalence (Marseille: 7.5% vs. Rome: 41.4%, p < 0.001) and of clinical characteristics was apparent. Cypress played a limited role, with only 1/22 SPT mono-sensitized patients reporting a food reaction (p < 0.073).
Conclusion: PFAS is a frequent comorbidity in Southern European SAR patients. Significant heterogeneity of clinical characteristics in PFAS patients among the centers was observed and may be related to the different pollen sensitization patterns in each geographic area. IgE to panallergen(s), maternal PFAS, and asthma could be PFAS-associated characteristics.
First Author:
Lipp T
Correspondence:
Paolo M. Matricardi Dept. of Paediatric Pneumology, Immunology and Critical Care Charitè Medical University Augustenburgerplatz, 1
2021-10-08 Article
　　創(chuàng)建過敏性疾病的科研、科普知識(shí)交流平臺(tái)，為過敏患者提供專業(yè)診斷、治療、預(yù)防的共享平臺(tái)。