原標(biāo)題：對LTP致敏的桃子過敏患者表型分型及嚴(yán)重程度的生物標(biāo)志物進(jìn)行分析
背景：對nsLTP致敏而導(dǎo)致桃子過敏的患者在致敏特性和嚴(yán)重程度方面構(gòu)成了一個特類。這可能是還存在其他的花粉過敏。本研究旨在分析兩個地中海地區(qū)不同花粉暴露下的對nsLTP致敏的桃子過敏患者的臨床特征、致敏情況和反應(yīng)的嚴(yán)重程度。
方法：從馬拉加地區(qū)大學(xué)（HRUM）和巴塞羅那醫(yī)院門診部（HCB）的過敏科診斷為LTP過敏的患者分為兩組：（a）單LTP過敏組：僅對桃子有反應(yīng)的患者；和（b）多LTP過敏組：與桃子和至少另一種含有LTP的植物性食物發(fā)生反應(yīng)。
結(jié)果：252例患者中，235例（93.2%）為LTP綜合征，17例（6.8%）為LTP無反應(yīng)性。我們發(fā)現(xiàn)在單LTP過敏組中，過敏反應(yīng)的百分比較高且癥狀發(fā)作延遲（分別為p=0.02和p=0.04）。此外，profilin致敏患者過敏反應(yīng)發(fā)生率較低（p=0.03）。HRUM與HCB數(shù)據(jù)比較顯示，患者對橄欖樹花粉和profilin的致敏性存在差異（分別為p=0.01和p=0.001）
結(jié)論：本研究發(fā)現(xiàn)兩個人群中超過90%的桃子過敏患者會演變?yōu)長TP過敏并表現(xiàn)出早期發(fā)作。作為嚴(yán)重程度的生物標(biāo)志物，Profilin的致敏性可能比nsLTP和吸入性過敏原的致敏性或sIgE水平更有用。本研究可能為其他地區(qū)相關(guān)的致敏性和嚴(yán)重程度模式提供線索。


延伸閱讀
Allergy                                                    
Phenotyping peach-allergic patients sensitised to LTP and analysing severity biomarkers
DOI: 10.1111/ALL.14447
Abstract:
Background: Patients with peach allergy due to nsLTP sensitisation constitute a heterogeneous group in terms of sensitisation profile and severity. This could be due to the presence of additional allergies to pollens. The aim of this study was to analyse the clinical characteristics, sensitization profile, and severity of reactions in peach-allergic patients sensitised to nsLTP from two Mediterranean areas with different pollen exposure.
Methods: Patients with diagnosis of LTP allergy from the Allergy Unit of Hospital Regional Universitario de Malaga (HRUM) and Hospital Clinic de Barcelona (HCB) were prospectively included and classified into two groups; (a) LTP-monoallergic: those that presented reaction only with peach, and (b) LTP-Allergy: those that presented reaction with peach and at least another plant-food containing LTP.
Results: 252 patients were included, 235 (93.2%) had LTP-syndrome and 17 (6.8%) were LTPmonoallergic. We found a higher percentage of anaphylaxis and delayed onset of symptoms in the LTP-monoallergic group (p=0.02 and p=0.04, respectively). Moreover, anaphylaxis was less frequent in patients with profilin sensitisation (p=0.03). The comparison of patients’ data from HRUM with data from HCB showed differences in sensitisation to olive tree pollen and profilin (p=0.01 and p=0.001, respectively).
Conclusion: This study was undertaken to characterize two large group of subjects from to two regions with differing exposures to pollen. We found that more than 90% of peach-allergic patients in both populations evolved to LTP-Allergy and showed an early onset. Profilin sensitisation could be more useful as a severity biomarker than the number of nsLTP, aeroallergen sensitisations, or sIgE levels. This could provide clues regarding sensitisation and severity patterns that might be relevant in other geographical areas.
First Author:
Bogas G  
Correspondence:
Allergy Service of the Hospital Regional Universitario de Málaga IBIMA- Hospital Regional Universitario de Málaga (Pavillion C). Plaza del Hospital Civil. 29009 Málaga, Spain
All Authors:
Bogas G, Mu?oz-Cano R, Mayorga C, Casas R, Bartra J, Pérez N, Pascal M , Palomares F, Torres MJ, Gómez F
2020-12-18 Article 
　　創(chuàng)建過敏性疾病的科研、科普知識交流平臺，為過敏患者提供專業(yè)診斷、治療、預(yù)防的共享平臺。