原標(biāo)題：IgE對(duì)Bet v 1同源物和抑制蛋白（profilin）無反應(yīng)的水果過敏患者中赤霉素調(diào)節(jié)蛋白(peamaclein)的致敏率高：赤霉素調(diào)節(jié)蛋白過敏的臨床模式、致敏水果和輔助因素
　?、俪嗝顾卣{(diào)節(jié)蛋白(GRP)是一種新發(fā)現(xiàn)的桃子過敏原，其氨基酸序列在多種植物中均有很好的保存。我們研究了GRP在桃子以外的水果過敏中的致敏性，并確定了GRP致敏的水果過敏患者的臨床特征。本研究以日本100例連續(xù)水果過敏患者為研究對(duì)象。為了確定GRP致敏的特征，我們選擇了Bet v1同源物和抑制蛋白（profilin）ImmunoCAP結(jié)果為陰性的患者，這兩者是花粉-食物過敏綜合征(PFAS) 的標(biāo)記過敏原或脂質(zhì)轉(zhuǎn)移蛋白。用純化的nPru p7通過酶聯(lián)免疫吸附試驗(yàn)(ELISA)對(duì)這些患者進(jìn)行特異性IgE檢測(cè)和皮膚點(diǎn)刺試驗(yàn)(SPT)。在100名連續(xù)水果過敏患者中，有20名患者的Bet v1同源物和profilinImmunoCAP檢測(cè)結(jié)果呈陰性。20例患者中13例(65.0%)ELISA和/或SPT結(jié)果為陽(yáng)性，而20例患者中有1例Pru p3ImmunoCAP結(jié)果為陽(yáng)性。在13例nPru p7敏感患者中，致敏食物為桃子(92.3%)、杏(61.5%)、桔子(46.2%)和蘋果(30.8%)。10例(76.9%)有多種致果性。常見的癥狀包括面部水腫(92.3%)和喉部緊張(66.7%)。在8例(61.5%)患者中，運(yùn)動(dòng)或服用阿司匹林作為輔助因素可增強(qiáng)過敏反應(yīng)的發(fā)生。除PFAS外，日本水果過敏患者GRP致敏率較高。總之，GRP敏感患者可能對(duì)多種水果過敏，并可能表現(xiàn)出特殊的特征，如面部腫脹和輔助因素依賴性。
延伸閱讀
JAD                                                    
High prevalence of sensitization to gibberellin‐regulated protein (peamaclein) in fruit allergies with negative immunoglobulin E reactivity to Bet v 1 homologs and profilin: Clinical pattern, causative fruits and cofactor effect of gibberellin‐regulated protein allergy
https://doi.org/10.1111/1346-8138.13795
Gibberellin‐regulated protein (GRP) is a new allergen in peach allergy, with an amino acid sequence very well conserved through several botanical species. We investigated the allergenicity of GRP in fruit allergies other than peaches and identified the clinical characteristics of fruit allergy patients with GRP sensitization. One hundred consecutive Japanese patients with fruit allergies were enrolled in the present study. To identify the features of GRP sensitization, we selected patients with negative ImmunoCAP results for Bet v 1 homologs and profilin, which are marker allergens for pollen‐food allergy syndrome (PFAS), or lipid transfer protein. These patients underwent specific immunoglobulin E measurements by enzyme‐linked immunosorbent assay (ELISA) and skin prick tests (SPT) using purified nPru p 7. Twenty of 100 consecutive patients with fruit allergies had negative ImmunoCAP results for Bet v 1 homologs and profilin. Thirteen (65.0%) of the 20 patients had positive ELISA and/or SPT results using nPru p 7, whereas one of the 20 patients had positive ImmunoCAP results for Pru p 3. In 13 nPru p 7‐sensitized patients, the causative foods were peaches (92.3%), apricots (61.5%), oranges (46.2%) and apples (30.8%). Ten patients (76.9%) had multiple causative fruits. Frequent symptoms included facial edema (92.3%) and laryngeal tightness (66.7%). In eight patients (61.5%), exercise or aspirin intake enhanced the allergic reaction onset as cofactors. The prevalence of GRP sensitization was high in Japanese fruit allergy patients except for PFAS patients. In conclusion, GRP‐sensitized patients may have allergies to multiple fruits and may show peculiar characteristics such as facial swelling and cofactor dependence.
All Author:
Naoko Inomata, M.D., Ph.D  Mami Miyakawa  Michiko Aihara
　　創(chuàng)建過敏性疾病的科研、科普知識(shí)交流平臺(tái)，為過敏患者提供專業(yè)診斷、治療、預(yù)防的共享平臺(tái)。