原標(biāo)題：肉類過(guò)敏及其過(guò)敏原
　　IgE介導(dǎo)的對(duì)攝入動(dòng)物產(chǎn)品(包括哺乳動(dòng)物和禽類)的超敏反應(yīng)日益被認(rèn)為是一種重要的食物過(guò)敏形式。傳統(tǒng)上主要描述兒童的情況，現(xiàn)在很清楚，對(duì)肉類(和動(dòng)物內(nèi)臟)的過(guò)敏影響兒童和成人，代表了一個(gè)異質(zhì)性的過(guò)敏性疾病群體，有多種不同的綜合征。隨著對(duì)豬貓綜合癥和遲發(fā)性紅肉過(guò)敏等的認(rèn)識(shí)，例如α-半乳糖綜合癥，其基本原理, 以及一些最近得到關(guān)注的病例的過(guò)敏特征已經(jīng)被搞清。包括對(duì)暴露途徑和致敏機(jī)制的深入了解，以及認(rèn)識(shí)到IgE介導(dǎo)的反應(yīng)可延遲數(shù)小時(shí)。在此，我們回顧了對(duì)哺乳動(dòng)物和禽類的肉過(guò)敏，重點(diǎn)介紹了導(dǎo)致疾病的分子過(guò)敏原和途徑，以及體外IgE檢測(cè)在診斷和管理中的作用。
延伸閱讀
Molecular Immunology  Volume 100, August 2018, Pages 107-112
Meat allergy and allergens
https://doi.org/10.1016/j.molimm.2018.03.018
Abstract:
Abstract
IgE-mediated hypersensitivity to ingested animal products, including both mammalian and avian sources, is increasingly appreciated as an important form of food allergy. Traditionally described largely in children, it is now clear that allergy to meat (and animal viscera) impacts both children and adults and represents a heterogeneous group of allergic disorders with multiple distinct syndromes. The recognition of entities such as pork-cat syndrome and delayed anaphylaxis to red meat, i.e- the α-Gal syndrome, have shed light on fundamental, and in some cases newly appreciated, features of allergic disease. These include insights into routes of exposure and mechanisms of sensitization, as well as the realization that IgE-mediated reactions can be delayed by several hours. Here we review mammalian and avian meat allergy with an emphasis on the molecular allergens and pathways that contribute to disease, as well as the role of in vitro IgE testing in diagnosis and management.
All Authors:
Jeffrey M.WilsonThomas A.E.Platts-Mills
　　創(chuàng)建過(guò)敏性疾病的科研、科普知識(shí)交流平臺(tái)，為過(guò)敏患者提供專業(yè)診斷、治療、預(yù)防的共享平臺(tái)。