原標(biāo)題：
　　氣道益生菌：可能改善上皮和免疫穩(wěn)態(tài)
　?、?益生菌是活著的微生物，適量使用可以給予宿主健康上的好處；② 本文描述了益生菌在氣道中可能的作用機(jī)制，特別著重于它們調(diào)節(jié)上皮屏障功能的能力及其與免疫系統(tǒng)的相互作用模式；③ 益生菌，主要是乳酸桿菌，可以促進(jìn)緊密連接和粘附連接的表達(dá)和調(diào)節(jié)，從而恢復(fù)有缺陷的上皮屏障；④ 這些益生菌通過模式識別受體(如類toll受體)與上皮屏障和免疫細(xì)胞相互作用，激活后可刺激或抑制各種免疫反應(yīng)。


　　延伸閱讀
Allergy
Probiotics for the Airways: potential to improve epithelial and immune homeostasis
DOI: 10.1111/all.13495
Abstract:
Probiotics are live microorganisms that confer a health benefit on the host when applied in adequate amounts. The therapeutic effects of probiotics have been mostly studied in the gastrointestinal tract, but recent evidence points towards the potential of these bacteria to prevent and/or treat chronic airway diseases. In this review, possible mechanisms of action of probiotics in the airways are described, with a particular focus on their capacity to modulate the epithelial barrier function and their mode of interaction with the immune system. Indeed, probiotic bacteria, mostly lactobacilli, can promote the expression and regulation of tight junctions and adherence junctions, resulting in the restoration of a defective epithelial barrier.These bacteria interact with the epithelial barrier and immune cells through pattern recognition receptors, such as toll-like receptors, which upon activation can stimulate or suppress various immune responses. Finally, the clinical potential of probiotics to treat inflammatory diseases of the upper and lower respiratory tract, and the difference between their mode of application (e.g. oral or nasal) are discussed here.
First Author:
Katleen Martens, Msc
Correspondence:
Clinical Division of Otorhinolaryngology, Head and Neck Surgery
All Authors:
Katleen Martens, Msc; Benoit Pugin, PhD; Ilke De Boeck, Msc; Irina Spacova, PhD;
Brecht Steelant, PhD; Sven F. Seys, PhD; Sarah Lebeer, PhD; Peter W. Hellings, PhD,MD
　　創(chuàng)建過敏性疾病的科研、科普知識交流平臺，為過敏患者提供專業(yè)診斷、治療、預(yù)防的共享平臺。