原標題：產(chǎn)前顆粒物質(zhì)通過氣道高反應(yīng)影響學(xué)齡兒童新哮喘發(fā)生
　　背景：學(xué)齡兒童在PM10下暴露影響氣道高反應(yīng)和哮喘新發(fā)展的相關(guān)時間尚不清楚。本研究的目的是研究PM10暴露對學(xué)齡兒童氣道高反應(yīng)最關(guān)鍵的時間和哮喘的新診斷。
　　方法：在2005年至2006之間遴選了3570位學(xué)齡兒童，個體每年的PM10暴露量是通過一種普通的克立格方法從產(chǎn)前到7歲估計的。
　　結(jié)果： 妊娠期和1歲時PM10暴露對患AHR有顯著影響（AOR:1.694，95%CI:1.298-2.209；AOR:1.750，95%CI:1.343-2.282）。妊娠期PM10暴露與新診斷哮喘的風(fēng)險相關(guān)（AOR:2.056，95%CI:1.240-3.409），兒童7歲時患AHR的風(fēng)險最高（AOR:6.080，95%CI:2.150-17.195）。妊娠中期PM10暴露與7歲AHR兒童患哮喘有最高風(fēng)險相關(guān)（AOR:4.136，95%CI:1.657-10.326）。
　　結(jié)論：妊娠中期的產(chǎn)前PM10暴露與7歲學(xué)齡兒童哮喘新診斷的風(fēng)險增加有關(guān)。這項研究表明，PM10在子宮內(nèi)特定三個月的暴露可能通過AHR影響兒童哮喘的發(fā)病。


　　延伸閱讀
Allergy：
Prenatal particulate matter affects new asthma via airway hyperresponsiveness in schoolchildren
DOI: 10.1111/all.13649
Abstract:
Background: The most relevant time of PM10 exposure to affect airway hyperresponsiveness (AHR) and new development of asthma in school‐aged children is unclear.The aims of this study were to investigate the most critical time of PM10 exposure to affect AHR and new diagnosis of asthma from AHR in school‐aged children.
Methods: Elementary schoolchildren (n = 3570) have been enrolled in a nationwide prospective 4‐year follow‐up survey in Korea from 2005 to 2006. Individual annual PM10 exposure was estimated by using an ordinary kriging method from the prenatal period to 7 years of age. AHR at 7 years was defined by a methacholine PC20≤8 mg/mL.
Results: PM10 exposure during pregnancy and at 1 year of age showed significant effects on AHR (aOR: 1.694, 95% CI: 1.298‐2.209; and aOR: 1.750, 95% CI: 1.343‐2.282, respectively). PM10 exposure during pregnancy was associated with the risk of a new diagnosis of asthma (aOR: 2.056, 95% CI: 1.240‐3.409), with the highest risk in children with AHR at age 7 (aOR: 6.080, 95% CI: 2.150‐17.195). PM10 exposure in the second trimester was associated with the highest risk of a new diagnosis of asthma in children with AHR at age 7 (aOR: 4.136, 95% CI: 1.657‐10.326).
Conclusions: Prenatal PM10 exposure in the second trimester is associated with an increased risk of a new diagnosis of asthma in school‐aged children with AHR at 7 years. This study suggests that PM10 exposure during a specific trimester in utero may affect the onset of childhood asthma via AHR .
First Author:
Song-I Yang
Correspondence:
Soo-Jong Hong, Department of Pediatrics,Childhood Asthma Atopy Center,Environmental Health Center, Asan Medical Center, University of Ulsan, College of Medicine, Seoul, Korea
All Authors:
Song-I Yang| So-Yeon Lee | Hyo-Bin Kim | Hwan-Cheol Kim| Jong-Han Leem |Hyeon‐Jong Yang| Hyeok Kwon | Ju-Hee Seo | Hyun-Ju Cho | Jisun Yoon |Eun Lee | Young-Ho Jung | Yeongho Kim | Sungsu Jung | Ho-Jang Kwon |Soo-Jong Hong
　　創(chuàng)建過敏性疾病的科研、科普知識交流平臺，為過敏患者提供專業(yè)診斷、治療、預(yù)防的共享平臺。