原標(biāo)題：食物特異性IgG4抗體不僅在小麥過敏的兒童中升高，胃腸疾病患兒中也會(huì)升高 
　?、俦尘笆澄飐IgG和sIg G4具有高度的個(gè)體多樣性。我們假設(shè)，胃腸道炎癥的存在是導(dǎo)致其產(chǎn)生的原因之一。本研究的目的是:1、對(duì)以下幾組兒童樣本進(jìn)行小麥和大米sIgG和sIgG4分析：健康兒童、IgE介導(dǎo)的小麥過敏(WA)、乳糜瀉(CD)和幽門螺桿菌感染(HP)。2。評(píng)價(jià)小麥sIgG和sIgG4檢測(cè)在小麥過敏診斷中的適用性。②我們比較了200名兒童的小麥和大米sIgG和sIgG4（總計(jì)388項(xiàng)）: 50 例小麥過敏(診斷、飲食治療、耐受)、50乳糜瀉(診斷和緩解)、50 幽門螺桿菌感染（HP）和50 例健康人。采用FEIA法(Pharmacia CAP系統(tǒng))測(cè)定SIgE、sIgG、sIgG4。③結(jié)果：健康兒童食品中sIgG最低，沒有發(fā)現(xiàn)sIgG4。乳糜瀉組以小麥和大米sIgG、大米sIgG4最為常見，其濃度最高。小麥sIgG4在小麥過敏兒童中過敏兒童(診斷和耐受)中最高，在飲食排除期間下降 (p < .05)。小麥和大米sIgG在所有過敏階段保持不變。大米sIgG和大米sIgG4沒有什么差異。④結(jié)論1.CD、HP和WA患兒血清中小麥和水稻sIgG和sIgG4濃度升高。2。某些胃腸道炎癥的亞臨床發(fā)生率可能是導(dǎo)致血清中食物sIgG和sIgG4濃度的高度個(gè)體多樣性的原因。3.兒童小麥sIgG和sIgG4的濃度與小麥過敏臨床表現(xiàn)不成對(duì)應(yīng)關(guān)系。


　　延伸閱讀
BMC Gastroenterology ：
Food IgG4 antibodies are elevated not only in children with wheat allergy but also in children with gastrointestinal diseases
https://doi.org/10.1186/s12876-016-0450-3
Abstract  ：
Food sIgG and sIgG4 are highly individually versatile. We put a hypothesis that one of the responsible factors is the presence of gastrointestinal inflammatory diseases. The objectives were: 1. An analysis of wheat and rice sIgG and sIgG4 in healthy children, children with IgE-mediated wheat allergy (WA), coeliac disease (CD) and Helicobacter pylori infection (HP). 2. Usability of wheat sIgG and sIgG4 in the WA diagnostics.
Methods
We compared 388 each wheat and rice sIgG and sIgG4 in a group of 200 children: 50 WA (diagnosis, diet treatment, tolerance), 50 CD (diagnosis and remission), 50 HP and 50 healthy. SIgE, sIgG, sIgG4 were determined with the FEIA method (Pharmacia CAP System).
Results
In healthy children food sIgG were the lowest; no sIgG4 were found. In the CD diagnosis group wheat and rice sIgG and rice sIgG4 were the most common and their concentrations were the highest. Wheat sIgG4 were the highest in WA children (diagnosis and tolerance) to fall during the elimination diet (p?<?.05). Wheat and rice sIgG remained the same in all allergy phases. Rice sIgG also did not differ in the class G4.
Conclusions
1.Serum concentrations of wheat and rice sIgG and sIgG4 are elevated in children with CD, HP and WA. 2. Sub-clinical incidence of some gastrointestinal inflammatory diseases may be responsible for high individual versatility of food sIgG and sIgG4 concentrations in serum. 3. Wheat sIgG and sIgG4 in children do not correlate with WA clinical picture.
All Authors：Gra?yna Czaja-Bulsa   Email author, Micha? Bulsa and Aneta G?bala
　　創(chuàng)建過敏性疾病的科研、科普知識(shí)交流平臺(tái)，為過敏患者提供專業(yè)診斷、治療、預(yù)防的共享平臺(tái)。