原標(biāo)題:黃花蒿舌下免疫療法治療季節(jié)性過敏性鼻炎:一項(xiàng)隨機(jī)對照試驗(yàn)
——浙大迪迅 譯
背景:黃花蒿是中國北方季節(jié)過敏性鼻炎(SAR)的一種重要秋季花粉過敏原。到目前為止,還沒有一項(xiàng)研究調(diào)查過黃花蒿過敏原免疫治療的情況。本研究旨在探討黃花蒿舌下免疫療法(SLIT)的療效和機(jī)制。
方法:這是一項(xiàng)隨機(jī)、雙盲、安慰劑對照的III期臨床試驗(yàn),共有71名SAR患者,隨機(jī)分為兩組,分別用黃花蒿提取物(n=47)或安慰劑(n=24)舌下免疫治療32周。在基線(上一年的峰值花粉期(PPP)),SLIT開始,SLIT期間的第1個PPP,SLIT結(jié)束和隨訪期間第2個PPP這幾個時段評估鼻總癥狀評分(TNSS;主要臨床終點(diǎn))。在SLIT開始和之后收集血液樣本和鼻分泌物,以評估T細(xì)胞和炎性介質(zhì)。根據(jù)報告的不良事件(AEs)評估安全性。
結(jié)果:在第一個PPP(P <.001)時,黃花蒿SLIT顯著降低TNSS至基線水平(從9.45±1.68降低至6.16±2.27),高于安慰劑(從9.29±2.09降低至9.05±2.40),并且上述改善一直持續(xù)到第二個 PPP。另外,季前性黃花蒿SLIT治療16周能夠顯著降低血液中的Th2細(xì)胞和增加nTreg和Tr1細(xì)胞;與預(yù)處理相比,治療后第16周和32周鼻分泌物中的半胱氨酸蛋白酶抑制劑1(CST1)升高??偟膩碚f,黃花蒿SLIT治療后,17/47名患者出現(xiàn)了輕度局部AEs,2名患者出現(xiàn)了輕度全身性AEs。
結(jié)論:黃花蒿SLIT是一種安全有效的黃花蒿SAR治療方法。
延伸閱讀
Allergy
[IF:6.771]
Artemisia annua-sublingual immunotherapy for seasonal allergic rhinitis:
A randomized controlled trial
DOI: 10.1111/all.14218
Abstract:
Background: Artemisia annua is an important autumnal pollen allergen for seasonal allergic rhinitis (SAR) in northern China. To date, no study has investigated allergen immunotherapy with A annua. We aimed to investigate the efficacy and mechanisms underlying A annua-sublingual immunotherapy (SLIT).
Methods: This was a randomized, double-blind, placebo-controlled phase III clinical trial involving 71 SAR patients, randomized to SLIT with A annua extract (n = 47) or placebo (n = 24) for 32 weeks. Total nasal symptom score (TNSS; primary clinical end point) was evaluated at baseline (peak pollen phase (PPP) in the previous year), initiation of A annua-SLIT, 1st PPP during SLIT, end of SLIT and 2nd PPP during follow-up. Blood samples and nasal secretions were collected at beginning and after SLIT for assessment of T cells and inflammatory mediators. Safety was assessed according to adverse events (AEs) reported.
Results: Artemisia annua-SLIT significantly reduced TNSS to a greater level from baseline (from 9.45 ± 1.68 to 6.16 ± 2.27) than placebo (from 9.29 ± 2.09 to 9.05 ± 2.40) at the 1st PPP (P < .001) and sustained the improvement in symptoms throughout to the 2nd PPP. Preseasonal A annua-SLIT for 16 weeks significantly decreased Th2 cells, increased nTreg and Tr1 cells in blood; and increased cystatin 1 (CST1) in nasal secretion after 16 and 32 weeks compared with pretreatment. Overall, 17/47 patients experienced mild local AEs and 2 patients mild systemic AEs, after A annua-SLIT.
Conclusion: Artemisia annua-SLIT is an efficacious and safe treatment in patients with A annua SAR.
First Author:
Hongfei Lou, Chengshuo Wang
Correspondence:
Chengshuo Wang, Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, No.1, Dongjiaominxiang, DongCheng District, Beijing 100730, China.
All Authors:
Hongfei Lou, Yanran Huang,Yuhui Ouyang,Yuan Zhang, Lin Xi, Xiaohan Chu, Yang Wang, Chengshuo Wang, Luo Zhang
2020-08-19 Article
創(chuàng)建過敏性疾病的科研、科普知識交流平臺,為過敏患者提供專業(yè)診斷、治療、預(yù)防的共享平臺。