原標(biāo)題：青春期早熟與兒童哮喘風(fēng)險(xiǎn)的孟德爾隨機(jī)化和縱向研究
背景：有關(guān)青春期早期和哮喘發(fā)作的研究報(bào)告了不一致的結(jié)果，并且主要集中在女性上。在這項(xiàng)縱向研究中，我們通過孟德爾隨機(jī)化（MR）調(diào)查了青春期成熟與哮喘之間的因果關(guān)系，并探討了超重和青春期早熟對哮喘的聯(lián)合影響。
方法：我們使用來自臺(tái)灣兒童健康研究的數(shù)據(jù)，對2991名11-17歲兒童進(jìn)行了縱向隨訪。六個(gè)青春期相關(guān)的SNPs（結(jié)合成加權(quán)等位基因得分）被用來作為青春期早期的遺傳工具變量。青春期早熟被定義為某個(gè)青春期早于該階段的中位年齡。通過排除在此年齡之前有哮喘病史的兒童來計(jì)算哮喘的發(fā)病率。
結(jié)果：MR分析的結(jié)果表明，青春期早熟與活動(dòng)性哮喘有關(guān)（OR = 1.18； 95％CI：1.08-1.28）； 這種作用在男孩中很明顯。青春期早熟顯著增加了男女在12和17歲時(shí)發(fā)生哮喘的風(fēng)險(xiǎn)（危險(xiǎn)比= 2.15； 95％CI：1.21-3.84）。 以非超重和非青春期早期兒童為參考組，我們觀察到超重和青春期早熟對男女兒童的哮喘風(fēng)險(xiǎn)具有協(xié)同作用（OR = 1.08； 95％CI：1.04-1.11）。
結(jié)論：建議及早進(jìn)行肥胖癥篩查和干預(yù)，以防止將來青春期早期哮喘的發(fā)生。


延伸閱讀
Allergy                                                
[IF:6.048]
Early pubertal maturation and risk of childhood asthma: A mendelian randomization and longitudinal study
DOI: 10.1111/all.14009
Abstract:
Background: Studies on early puberty and incident asthma have reported inconsistent results and are mainly performed in females. In this longitudinal study, we investigated the causal relationship between pubertal maturation and asthma through Mendelian randomization (MR) and explored the joint effect of overweightness and early pubertal maturation on asthma. 
Methods: We used data from the Taiwan Children Health Study with longitudinal follow‐ups of 2991 children aged 11‐17 years. Six puberty‐related single‐nucleotide polymorphisms (combined into a weighted allelic score) were used to yield genetic instrumental variables for early puberty. Early pubertal maturation was defined as reaching a certain pubertal stage earlier than the median age for that stage. Incident asthma cases were calculated by excluding children with a history of asthma prior to that age.
Results: The results of MR analysis revealed that early pubertal maturation was associated with active asthma (OR = 1.18; 95% CI: 1.08‐1.28); This effect was significant in male children. Early pubertal maturation significantly increased the risk of incident asthma outcomes at 12 and 17 years of age in both sexes (hazard ratio = 2.15; 95% CI: 1.21‐3.84). Taking non‐overweight and non–early puberty children as the reference group, we observed a synergistic effect of overweightness and early pubertal maturation on asthma risk (OR = 1.08; 95% CI: 1.04‐1.11) in children of both sexes.
Conclusion: Early screening and intervention for obesity are recommended to prevent future early pubertal onset and asthma occurrence.
First Author:
Yang‐Ching Chen 
Correspondence:
Department of Family Medicine, Taipei Medical University Hospital, Taipei Medical University, No. 252,Wuxing St, Xinyi District, Taipei 110, Taiwan, China
All Authors:
Yang‐Ching Chen, Hsien‐Yu Fan, Chen Yang, Yungling L. Lee
　　創(chuàng)建過敏性疾病的科研、科普知識交流平臺(tái)，為過敏患者提供專業(yè)診斷、治療、預(yù)防的共享平臺(tái)。