原標(biāo)題：老年婦女非特應(yīng)性濕疹:空氣污染和基因的影響
　?、匐m然兒童特應(yīng)性濕疹的危險(xiǎn)因素很多，但對中老年人濕疹的表型知之甚少。②我們試圖研究空氣污染、特異反應(yīng)性和成年濕疹之間的關(guān)系。③這項(xiàng)分析是基于834名德國婦女的研究，該研究是關(guān)于空氣污染對肺功能、炎癥和衰老的影響。采用第二次隨訪(2007-2010)的問卷調(diào)查方法，對55歲以后濕疹的發(fā)病癥狀和調(diào)查前12個(gè)月及以下濕疹的流行癥狀進(jìn)行評估。在基線(1985-1994)和2007-2010年測量血清總IgE水平。采用土地利用回歸法評價(jià)了空氣污染的暴露程度。采用調(diào)整后的邏輯回歸模型來估計(jì)空氣污染與濕疹和流行癥狀之間的關(guān)系。加權(quán)遺傳風(fēng)險(xiǎn)評分用于研究特應(yīng)性濕疹相關(guān)風(fēng)險(xiǎn)等位基因?qū)@種關(guān)聯(lián)的影響。④接觸氧化氮(二氧化氮和氮氧化物)和可吸入顆粒物(細(xì)顆粒物空氣動力學(xué)直徑≤2.5μm [PM2.5]和顆粒物的空氣動力學(xué)直徑< 10μm)與濕疹發(fā)病的可能性之間有顯著的相關(guān)性(例如, PM2.5每4.7μg /立方米;比值比,1.45;95%可信區(qū)間,1.06 - -1.99)。這些關(guān)聯(lián)在非特應(yīng)性濕疹中更為明顯; (如PM2.5,對于沒有花粉熱或IgE水平升高的參與者，優(yōu)勢比為1.65,95%可信區(qū)間為1.15-2.34)。對特應(yīng)性濕疹風(fēng)險(xiǎn)等位基因較少的攜帶者來說，空氣污染與濕疹的相關(guān)性更強(qiáng)。⑤老年人非特應(yīng)性濕疹與交通相關(guān)的空氣污染物有關(guān)，其表型與遺傳性特應(yīng)性濕疹不同。
延伸閱讀
JACI    Volume 143, Issue 1, January 2019, Pages 378-385
Nonatopic eczema in elderly women: Effect of air pollution and genes
https://doi.org/10.1016/j.jaci.2018.09.031
Background
Although many risk factors have been described for atopic eczema in children, little is known about the eczema phenotype in middle-aged or elderly adults.
Objective
We sought to examine the association between air pollution, atopy, and eczema in adulthood.
Methods
This analysis was based on 834 women from the Study on the influence of Air pollution on Lung Function, Inflammation and Ageing cohort in Germany. Incident symptoms of eczema after age 55 years and prevalent symptoms of eczema 12 months or less before investigation were assessed by means of questionnaire at the second follow-up (2007-2010). Total serum IgE levels were measured at baseline (1985-1994) and in 2007-2010. Exposure to air pollution was assessed by using land-use regression. Adjusted logistic regression models were applied to estimate the association between air pollution and incident and prevalent symptoms of eczema. Weighted genetic risk scores were used to investigate the effect of atopic eczema–related risk alleles on this association.
Results
Exposures to oxides of nitrogen (nitrogen dioxide and nitrogen oxides) and particulate matter (fine particulate matter with an aerodynamic diameter of ≤2.5 μm [PM2.5] and particulate matter with an aerodynamic diameter of <10 μm) were significantly associated with increased odds of incident eczema (eg, with PM2.5 per 4.7 μg/m3; odds ratio, 1.45; 95% CI, 1.06-1.99). These associations were slightly more pronounced with nonatopic eczema (eg, with PM2.5; odds ratio of 1.65 and 95% CI of 1.15-2.34 for participants without hay fever or increased IgE levels). Associations with air pollution were stronger in carriers of fewer risk alleles for atopic eczema.
Conclusion
Nonatopic eczema in the elderly is associated with traffic-related air pollutants, and this phenotype differs from genetically driven atopic eczema.
All Author:
AnkeHülsPhDa?Michael J.AbramsonPhDab?DorotheaSugiriMScaKaterynaFuksPhDaUrsulaKr?merPhDaJeanKrutmannMDacTamaraSchikowskiPhDa
　　創(chuàng)建過敏性疾病的科研、科普知識交流平臺，為過敏患者提供專業(yè)診斷、治療、預(yù)防的共享平臺。