原標(biāo)題：表觀遺傳與過敏：從基礎(chǔ)機理到臨床應(yīng)用
　　在西方，過敏性疾病在上升，眾所周知的過敏保護與驅(qū)動因素如微生物和飲食暴露、污染和吸煙通過改變表觀遺傳景觀來介導(dǎo)它們的影響力。這里，我們回顧了過敏性疾病中參與的表觀遺傳學(xué)改變，總結(jié)和批判性地評估表觀遺傳學(xué)相關(guān)研究中經(jīng)驗教訓(xùn)。我們展示了表觀遺傳學(xué)在臨床中的各種應(yīng)用：作為診斷工具，評估免疫治療后的耐受或在早期可能性地預(yù)測治療的效果。另外，新的技術(shù)進步如表觀基因組編輯一種脫氧核酶在將來可以對表觀基因組進行目標(biāo)性的修飾并提供新的治療工具。


　　延伸閱讀
Epigenomics  
Epigenetics  and allergy: from basic mechanisms to clinical applications
DOI
Abstract:
Allergic diseases are on the rise in the Western world and well-known allergy protecting and -driving factors such as microbial and dietary exposure, pollution and smoking mediate their influence through alterations of the epigenetic landscape.Here, we review key facts on the involvement of epigenetic modifications in allergic diseases and summarize and critically evaluate the lessons learned from epigenome-wide association studies. We show the potential of epigenetic changes for various clinical applications: as diagnostic tools, to assess tolerance following immunotherapy or possibly predict the success of therapy at an early time point. Furthermore, new technological advances such as epigenome editing an DNAzymes will allow targeted alterations of the epigenome in the future and provide novel therapeutic tools.
First Author:
DP Potaczek ， H Harb ， S Michel ， BA Alhamwe ， H Renz ， ...
　　創(chuàng)建過敏性疾病的科研、科普知識交流平臺，為過敏患者提供專業(yè)診斷、治療、預(yù)防的共享平臺。