原標(biāo)題：屋塵螨分子致敏模式從生命的第一年開始形成，包括第 1 組、第 2 組、Der p 23、Der p 5、Der p 7 和 Der p 21
背景：由于對塵螨（HDM）產(chǎn)生敏感性的過程和性質(zhì)尚未得到充分研究，因此我們的目標(biāo)是確定烏克蘭塵螨過敏患者致敏發(fā)展的模式、性質(zhì)和時(shí)間框架，以及對此類患者的治療最有效的時(shí)期。
方法：數(shù)據(jù)來自使用Alex2多重過敏檢測的20333名患者。使用描述性統(tǒng)計(jì)數(shù)據(jù)確定致敏的年齡特征，使用貝葉斯網(wǎng)絡(luò)分析建立個(gè)體致敏的概率模式。
結(jié)果：來自烏克蘭的患者最常對第1組（Der p 1，Der f 1）和第2組（Der p 2，Der f 2）的HDM過敏原組分以及Der p 23（55%）過敏。還觀察到對Der p 5、Der p 7和Der p 21有相當(dāng)大的敏感性。烏克蘭人口對HDM過敏原組分的總體致敏性質(zhì)是在出生第一年內(nèi)形成的。此時(shí)，對第1組和第2組的HDM過敏原組分以及Der p 23有明顯的致敏作用。對Der p 5、Der p 7和Der p 21過敏原組分的致敏意義從3~6歲開始增加。貝葉斯網(wǎng)絡(luò)數(shù)據(jù)分析表明，對Der p 1和Der f 2的致敏起主導(dǎo)作用。在發(fā)展對第5組過敏原組分的敏感性時(shí)，主導(dǎo)作用可能來源于Der p 21。
結(jié)論：本研究所獲得的結(jié)果表明了使用多組分方法確定致敏譜的重要性。由于HDM的致敏模式是在生命的第一年形成的，因此需要對AIT處方的最佳年齡進(jìn)行更詳細(xì)的研究。


延伸閱讀
Clinical and Molecular Allergy 
Molecular sensitization pattern to house dust mites is formed from the first years of life and includes group 1, 2, Der p 23, Der p 5, Der p 7 and Der p 21 allergens
DOI: org/10.1186/s12948-022-00182-z
Abstract:
Background: As the process and nature of developing sensitivity to house dust mites (HDMs) remain not fully studied,our goal was to establish the pattern, nature and timeframe of house dust mite (HDM) sensitization development in patients in Ukraine as well as the period when treatment of such patients would be most effective.
Method: The data of the multiplex allergy test Alex2 was collected from 20,033 patients. To determine age specifics of sensitization, descriptive statistics were used. Bayesian Network analysis was used to build probabilistic patterns of individual sensitization.
Results: Patients from Ukraine were most often sensitized to HDM allergens of group 1 (Der p 1, Der f 1) and group 2 (Der p 2, Der f 2) as well as to Der p 23 (55%). A considerable sensitivity to Der p 5, Der p 7 and Der p 21 allergens was also observed. The overall nature of sensitization to HDM allergens among the population of Ukraine is formed within the first year of life. By this time, there is a pronounced sensitization to HDM allergens of groups 1 and 2 as well as to Der p 23. Significance of sensitization to Der p 5, Der p 7 and Der p 21 allergens grows starting from the age of 3–6.Bayesian Network data analysis indicated the leading role of sensitization to Der p 1 and Der f 2. While developing the sensitivity to group 5 allergens, the leading role may belong to Der p 21 allergen.
Conclusion: The results obtained indicate the importance of determining the sensitization profile using the multicomponent approach. A more detailed study of the optimal age for AIT prescription is required as the pattern of sensitization to HDMs is formed during the first year of life.
First Author:
Serhii Yuriev
Corresponding author:
Andrii Kurchenko
Correspondence:
Department of Clinical Immunology and Allergology, Bohomolets National Medical University, Kiev, Ukraine