原標(biāo)題：塵螨致敏患者過敏原組份診斷
　　①背景：分子過敏診斷的應(yīng)用可以提高特異性過敏原免疫治療的療效②方法：在2018年的5個月內(nèi)，以437例年齡在34.6±5.4 歲的患者（其中56.1% 男性，43.9% 女性）為對象，使用Raptor Analysis MADx (kUA/L)對屋塵螨敏感的患者進行allergochip ALEX主要過敏原組份評估。③結(jié)果：106例(24.3%)對屋塵螨敏感。89例(83.9%)血清總IgE升高(294±4.3)。屋塵螨主要成分陽性情況如下:Der p 2  88例(83.1%)；Der p 1  48例 (45.3%);Der p 23  48例(45.3%)；Der p 5  25 例(23.6%)；Der p 7  18例 (17.0%)；和Der p11  9 例(8.5%)；粉塵螨的主要成分:Der f 1  67 例(63.2%)， Der f 2  65 例(61.3%);原肌球蛋白Der p10  9例(8.5%)。以主要過敏原Der p2和Der f1為主，范圍從0.12 kU/l到38.2 kU/l，但只有4例(3.8%)只對Der p 5敏感；3例(2.8%)只對Der p23敏感；1例(0.9%)只對Der p11敏感；而9例(8.5%)對主要過敏原 Der p 5, 7, 11均敏感的病人，他們對這三種組份的特異性IgE水平比對Der p 2 和/或Der p 1的特異性IgE水平更高（p<0.05）。④結(jié)論：對室內(nèi)塵螨敏感的患者可能對Der p1、Der p2同時敏感，對Der p5、7、11和23的特異性IgE的存在，提示應(yīng)優(yōu)化AIT制劑，使之含有多種過敏原組分。
延伸閱讀
JACI
Allergen Component Diagnosis of Patients with House Dust Mite Sensitization
DOI: https://doi.org/10.1016/j.jaci.2018.12.718
Rationale
The use of molecular allergy diagnostics may enhance specific allergen immunotherapy (AIT).
Methods
437 patients aged 34.6±5.4 years, 56.1% males 43.9% females, were assessed over five months in 2018. The allergochip ALEX allowing major allergen component assessment was performed on patients sensitized to house dust mites, using Raptor Analysis MADx, (kUA/L).
Results  
106 (24.3%) were dust mite sensitized. Total serum IgE was elevated (294±4.3) in 89 (83.9%) individuals. Major components of D. Pteronyssinus seen were: Der p 2 – in 88 (83.1%); Der p 1 -in 48 (45.3%); Der p 23 – in 48 (45.3%); Der p 5 – in 25 (23.6%); Der p 7 – in 18 (17.0%); and Der p 11 – in 9 (8.5%) ; major components of D. Farinae: Der f 1 – in 67 (63.2%), Der f 2 – in 65 (61.3%); and tropomyosin Der p 10 in 9 (8.5%) of patients. Major components of Der p 2 and Der f 1 dominated, ranging from 0.12 kU/l to 38.2 kU/l, but 4 (3.8%) were sensitized only to Der p 5; 3 (2.8%) to Der p 23; 1 (0.9%) to Der p 11; and 9 (8.5%) co-sensitized to major components Der p 5, 7, 11 at higher levels (p<0.05) of sIgE, than to Der p 2 and/or Der p 1.
Conclusions
Patients with sensitization to house dust mites may have combinations of sensitization to Der p 1 and Der p 2 and sIgE to Der p 5, 7, 11 and 23 suggesting optimization of AIT may require presence of multiple allergen components.
All Authors:
A. Kurchenko G. Fedoruk
· Bogomolets National Medical University, Kiev, Ukraine
1. S. YurievLawrence M. Dubuske
Corresponding Author
E-mail address:Claudiagray.paediatrics@gmail.com
Division of Allergology, Red Cross War Memorial Children's Hospital, Cape Town, South Africa
Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa
Correspondence
Claudia Gray, Department of Allergology, Red Cross War Memorial Children's Hospital, Klipfontein Road, Cape Town 7700, South Africa
Tel.: +27 21 4066889
Fax: +27 21 4066888
E‐mail: Claudiagray.paediatrics@gmail.com
　　創(chuàng)建過敏性疾病的科研、科普知識交流平臺，為過敏患者提供專業(yè)診斷、治療、預(yù)防的共享平臺。