原標(biāo)題：分子學(xué)過(guò)敏原特異性IgE檢測(cè)是基于過(guò)敏原提取物的致敏性分析的補(bǔ)充
　　基于過(guò)敏原分子組份分析的診斷性的IgE抗體檢測(cè)已經(jīng)以單一和多重陣列檢測(cè)的形式出現(xiàn)。他們同時(shí)使用天然和重組的過(guò)敏原分子(有時(shí)相互結(jié)合)來(lái)補(bǔ)充基于提取物的過(guò)敏原IgE抗體分析?？色@得的致敏分子總數(shù)已達(dá)到有助于診斷的水平;然而，需要更多的分子來(lái)涵蓋所有臨床上重要過(guò)敏原的特異性。因此，在可預(yù)見(jiàn)的未來(lái)，分子過(guò)敏原特異性IgE分析仍將是過(guò)敏原提取物IgE抗體分析在過(guò)敏診斷中的補(bǔ)充。因此，它將促使制造商能夠提高用于體外檢測(cè)的提取物的質(zhì)量。與組份診斷檢測(cè)相關(guān)的兩個(gè)最喜人的診斷進(jìn)展是，有可能通過(guò)包含當(dāng)前提取物和體外分析中未充分表達(dá)的過(guò)敏原來(lái)提高診斷靈敏度，并通過(guò)考慮過(guò)敏原交叉反應(yīng)性信息來(lái)提高診斷特異性。特別是后者的應(yīng)用仍在開(kāi)發(fā)中。這就需要進(jìn)一步研究血清學(xué)交叉反應(yīng)的臨床相關(guān)性。2015美國(guó)過(guò)敏、哮喘與免疫學(xué)學(xué)會(huì)(J Allergy Clin Immunol Pract 2015;3:863-9)


延伸閱讀
JACI：
Molecular Allergen-Specific IgE Assays as a Complement to Allergen Extract-Based Sensitization Assessment
http://dx.doi.org/10.1016/j.jaip.2015.09.013
Molecular allergen- based component-resolved diagnostic IgE antibody tests have emerged in the form of singleplex assays and multiplex arrays. They use both native and recombinant allergen molecules, sometimes in combination with each other, to supplement allergen extract-based IgE antibody analyses. The total number of available allergenic molecules has reached a diagnostically useful level; however, more molecules are needed to cover all the clinically important allergen specificities. Thus, for the foreseeable future, molecular allergen-specific IgE analyses will remain a supplement for initial allergen extract-based IgE antibody analyses in the diagnostic workup of the allergic patient. As a spin-off, it will enable manufacturers to improve the quality of extracts for in vitro testing. The 2 most exciting diagnostic developments linked to component-resolved diagnostic tests are the possibility to increase diagnostic sensitivity by the inclusion of allergens that are underrepresented in the current extracts and in vitro assays and to increase the diagnostic specificity by taking the information on allergen cross-reactivity into account. Particularly the latter application is still under development. This requires additional studies on the clinical relevance of serological cross-reactivity.  2015 American Academy of Allergy, Asthma & Immunology ( J Allergy Clin Immunol Pract 2015;3:863-9)
All Authors:
Rob C.AalbersePhDabJoost A.AalberseMD
　　創(chuàng)建過(guò)敏性疾病的科研、科普知識(shí)交流平臺(tái)，為過(guò)敏患者提供專(zhuān)業(yè)診斷、治療、預(yù)防的共享平臺(tái)。