原標題：兒童季節(jié)性變應性鼻炎的花粉-食物綜合征內(nèi)行：分子分類
　?、?花粉-食物綜合征(PFS)在觸發(fā)、嚴重程度、自然病史、并發(fā)癥和對治療的反應方面具有異質(zhì)性；② 納入1271名意大利兒童，使用ImmunoCAP FEIA測定泛過敏源Phl p 12 (profilin), Bet v 1 (PR-10), 和Pru p 3 (nsLTP)的IgE；④ 在一個以多次接觸花粉為特征的地中海國家，PFS是兒童SAR復雜而頻繁的并發(fā)癥，具有五種不同的內(nèi)型，以特異性IgE對泛變應原的敏感性為特征。


延伸閱讀


Allergy
Endotypes of pollen-food syndrome in children with seasonal allergic rhinoconjunctivitis: a molecular classification
DOI: 10.1111/all.12888
Abstract:
Background: Pollen-food syndrome (PFS) is heterogeneous with regard to triggers,severity, natural history, comorbidities, and response to treatment. Our study aimed to classify different endotypes of PFS based on IgE sensitization to panallergens.
Methods: We examined 1271 Italian children (age 4–18 years) with seasonal allergic rhinoconjunctivitis (SAR). Foods triggering PFS were acquired by questionnaire. Skin prick tests were performed with commercial pollen extracts. IgE to panallergens Phl p 12 (profilin), Bet v 1 (PR-10), and Pru p 3 (nsLTP) were tested by ImmunoCAP FEIA. An unsupervised hierarchical agglomerative clustering method was applied within PFS population.
Results: PFS was observed in 300/1271 children (24%). Cluster analysis identified five PFS endotypes linked to panallergen IgE sensitization: (i) cosensitization to≥2 panallergens (‘multi-panallergen PFS’); (ii–iv) sensitization to either profilin,or nsLTP, or PR-10 (‘mono-panallergen PFS’); (v) no sensitization to panallergens (‘no-panallergen PFS’). These endotypes showed peculiar characteristics: (i)‘multi-panallergen PFS’: severe disease with frequent allergic comorbidities and multiple offending foods; (ii) ‘profilin PFS’: oral allergy syndrome (OAS) triggered by Cucurbitaceae; (iii) ‘LTP PFS’: living in Southern Italy, OAS triggered by hazelnut and peanut; (iv) ‘PR-10 PFS’: OAS triggered by Rosaceae; and (v) ‘no-panallergen PFS’: mild disease and OAS triggered by kiwifruit.
Conclusions: In a Mediterranean country characterized by multiple pollen exposures, PFS is a complex and frequent complication of childhood SAR, with five distinct endotypes marked by peculiar profiles of IgE sensitization to panallergens. Prospective studies in cohorts of patients with PFS are now required to test whether this novel classification may be useful for diagnostic and therapeutic purposes in the clinical practice.
First Author:
C. Mastrorilli
Correspondence:
Matricardi, Department of Pediatric Pneumology and Immunology, Charite Medical University, Augustenburger Platz
All Authors:
C. Mastrorilli, S. Tripodi, C. Caffarelli1, S. Perna, A. Di Rienzo-Businco, I. Sfika, R. Asero, A. Dondi, A. Bianchi, C. Povesi Dascola, G. Ricci, F. Cipriani, N. Maiello, M. Miraglia Del Giudice, T. Frediani, S. Frediani, F. Macr?, C. Pistoletti, I. Dello Iacono, M. F. Patria,E. Varin, D. Peroni, P. Comberiati, L. Chini, V. Moschese, S. Lucarelli, R. Bernardini,G. Pingitore, U. Pelosi, R. Olcese, M. Moretti, A. Cirisano, D. Faggian, A. Travaglini,M. Plebani, M. C. Verga, M. Calvani, P. Giordani&P. M.
　　創(chuàng)建過敏性疾病的科研、科普知識交流平臺，為過敏患者提供專業(yè)診斷、治療、預防的共享平臺。