原標(biāo)題：世界衛(wèi)生組織/國(guó)際免疫學(xué)聯(lián)合會(huì)過(guò)敏原命名法：提供一種通用的術(shù)語(yǔ)
　　過(guò)敏原的系統(tǒng)命名起源于20世紀(jì)80年代早期，當(dāng)時(shí)只有很少蛋白質(zhì)過(guò)敏原被描述。David G. Marsh博士領(lǐng)導(dǎo)的科學(xué)家團(tuán)隊(duì)基于Linnaean分類(lèi)法發(fā)明了一種命名法，并在1986年進(jìn)一步建立了世界衛(wèi)生組織/國(guó)際免疫學(xué)會(huì)聯(lián)盟(WHO/IUIS)過(guò)敏原命名小組委員會(huì)。它的目的是標(biāo)準(zhǔn)化抗原(過(guò)敏原)的名稱，這些抗原(過(guò)敏原)在人類(lèi)中引起IgE介導(dǎo)的過(guò)敏。小組委員會(huì)于一九八六年首次發(fā)表修訂后的過(guò)敏原名單，直至一九九四年，該名單的數(shù)量不斷增加。從1994年到2007年，該數(shù)據(jù)庫(kù)是一個(gè)在線文本表格，隨后轉(zhuǎn)變?yōu)橐粋€(gè)更容易更新的網(wǎng)站。過(guò)敏原列表成為過(guò)敏原命名數(shù)據(jù)庫(kù)(www.allergen.org)，目前包含了大約880種不同來(lái)源的蛋白質(zhì)。小組委員會(huì)包括臨床和分子變態(tài)反應(yīng)學(xué)專(zhuān)家。他們使用小組委員會(huì)制定的以證據(jù)為基礎(chǔ)的標(biāo)準(zhǔn)來(lái)審查提交的過(guò)敏原候選蛋白。審查過(guò)程評(píng)估提交的過(guò)敏原生化分析報(bào)告和證據(jù)，目的是在發(fā)布前確定過(guò)敏原名稱。該小組委員會(huì)負(fù)責(zé)維護(hù)和修訂數(shù)據(jù)庫(kù)，并應(yīng)對(duì)不斷出現(xiàn)的挑戰(zhàn)，因?yàn)樾碌摹敖M學(xué)”技術(shù)提供了越來(lái)越多關(guān)于潛在新過(guò)敏原的數(shù)據(jù)。大多數(shù)期刊發(fā)表新過(guò)敏原信息都需要一個(gè)正式的過(guò)敏原名稱，包括向世衛(wèi)組織/IUIS過(guò)敏原命名小組委員會(huì)提交機(jī)密數(shù)據(jù)，來(lái)證明過(guò)敏樣本血清與純化蛋白的結(jié)合。


延伸閱讀
Molecular Immunology
WHO/IUIS Allergen Nomenclature: Providing a common language
https://doi.org/10.1016/j.molimm.2018.03.003
Abstract:
A systematic nomenclature for allergens originated in the early 1980s, when few protein allergens had been described. A group of scientists led by Dr. David G. Marsh developed a nomenclature based on the Linnaean taxonomy, and further established the World Health Organization/International Union of Immunological Societies (WHO/IUIS) Allergen Nomenclature Sub-Committee in 1986. Its stated aim was to standardize the names given to the antigens (allergens) that caused IgE-mediated allergies in humans. The Sub-Committee first published a revised list of allergen names in 1986, which continued to grow with rare publications until 1994. Between 1994 and 2007 the database was a text table online, then converted to a more readily updated website. The allergen list became the Allergen Nomenclature database (www.allergen.org), which currently includes approximately 880 proteins from a wide variety of sources. The Sub-Committee includes experts on clinical and molecular allergology. They review submissions of allergen candidates, using evidence-based criteria developed by the Sub-Committee. The review process assesses the biochemical analysis and the proof of allergenicity submitted, and aims to assign allergen names prior to publication. The Sub-Committee maintains and revises the database, and addresses continuous challenges as new “omics” technologies provide increasing data about potential new allergens. Most journals publishing information on new allergens require an official allergen name, which involves submission of confidential data to the WHO/IUIS Allergen Nomenclature Sub-Committee, sufficient to demonstrate binding of IgE from allergic subjects to the purified protein.
First Author:
Correspondence:
All Authors:
AnnaPomésaJanetM.DaviesbChristianeHilgerdThomasHolzhausereJonasLidholmfAndreas L.LopatagGeoffreyA.MuellerhAndreasNandyiChristianRadauerjSannyK.ChankUtaJappelJ?rgKleine-TebbemWayneR.ThomasnMartinD.ChapmanaMariannevanHageoRonaldvanReepStefanViethsq…Richard E.Goodmans
　　創(chuàng)建過(guò)敏性疾病的科研、科普知識(shí)交流平臺(tái)，為過(guò)敏患者提供專(zhuān)業(yè)診斷、治療、預(yù)防的共享平臺(tái)。