原標題：貓毛組分敏感與青年哮喘2型生物標志物有關(guān)聯(lián)
　?、?貓毛敏感的分子模式因人而異，它們與哮喘患者炎癥的關(guān)系還沒有得到廣泛的研究；② 納入哮喘病人266人（10-35歲），其IgE對貓毛、狗毛和馬毛敏感（ImmunoCAP），分析IgE對貓毛過敏原成分Fel d1(分泌球蛋白)、Fel d2(血清白蛋白)、Fel d4、Fel d7(脂蛋白)的影響；③ IgE對Fel d2的水平與FeNO (p=0.012)和總IgE (p<0.001)有相關(guān)；④IgE對于Fel d 1和貓毛提取的炎癥標記物無任何關(guān)聯(lián)(p = 0.23?0.51)；⑤ 青年哮喘患者血清中IgE對脂蛋白(Fel d 4)和血清白蛋白(Fel d 2)的水平與2型生物標志物和總IgE含量相關(guān)。


　　延伸閱讀


Clinical & Experimental Allergy
Sensitisation to minor cat allergen components is associated with type-2 biomarkers in young asthmatics
DOI: 10.1111/cea.13135
Abstract:
Background: Cat allergy is a major trigger of asthma worldwide. Molecular patterns of cat sensitisationvary between individuals, but their relationship to inflammation in asthmatics has not beenextensively studied.
Methods: Patients with asthma (age 10?35 years; n=266) and IgE sensitisation to cat, dog or horse extract (ImmunoCAP), were analysed for IgE to the cat allergen components Fel d 1 (secretoglobin), Fel d 2 (serum albumin), Fel d 4 and Fel d 7 (lipocalins). Independent associations between IgE-antibody concentrations, and fraction of exhaled nitric oxide (FeNO), blood eosinophil (B-Eos) count, and total IgE were analysed by multiple linear regression after adjustment for possible confounders.
Results: The level of IgE against Fel d 2 was independently related to FeNO (p=0.012) and total IgE (p<0.001), and IgE against Fel d 4 associated with Β-Eos count (p=0.009) and total IgE (p<0.001). IgE antibodies against Fel d 1 or cat extract did not independently relate to these inflammatory markers (p=0.23?0.51).
Conclusions: Levels of IgE to lipocalin (Fel d 4) and serum albumin (Fel d 2), but not to secretoglobin (Fel d 1) or cat extract, were independently associated with type-2 biomarkers and total IgE in young asthmatics.
First Author:
Tsolakis N.
Correspondence:
Department of Women’s and Children’s Health, Uppsala University
All Authors:
Tsolakis N, Malinovschi A, Nordvall L, Mattsson L, Lidholm J, Pedroletti C, Janson C, Borres M.P, and Alving K
　　創(chuàng)建過敏性疾病的科研、科普知識交流平臺，為過敏患者提供專業(yè)診斷、治療、預(yù)防的共享平臺。