杭州浙大迪迅生物基因工程有限公司Release date：2018-11-13
Epigenomics
DOI
Abstract:
Allergic diseases are on the rise in the Western world and well-known allergy protecting and -driving factors such as microbial and dietary exposure, pollution and smoking mediate their influence through alterations of the epigenetic landscape.Here, we review key facts on the involvement of epigenetic modifications in allergic diseases and summarize and critically evaluate the lessons learned from epigenome-wide association studies. We show the potential of epigenetic changes for various clinical applications: as diagnostic tools, to assess tolerance following immunotherapy or possibly predict the success of therapy at an early time point. Furthermore, new technological advances such as epigenome editing an DNAzymes will allow targeted alterations of the epigenome in the future and provide novel therapeutic tools.
First Author:
DP Potaczek ， H Harb ， S Michel ， BA Alhamwe ， H Renz ， ...
[IF:6.048]
Epigenetics and allergy: from basic mechanisms to clinical applicationsDOI
Abstract:
Allergic diseases are on the rise in the Western world and well-known allergy protecting and -driving factors such as microbial and dietary exposure, pollution and smoking mediate their influence through alterations of the epigenetic landscape.Here, we review key facts on the involvement of epigenetic modifications in allergic diseases and summarize and critically evaluate the lessons learned from epigenome-wide association studies. We show the potential of epigenetic changes for various clinical applications: as diagnostic tools, to assess tolerance following immunotherapy or possibly predict the success of therapy at an early time point. Furthermore, new technological advances such as epigenome editing an DNAzymes will allow targeted alterations of the epigenome in the future and provide novel therapeutic tools.
First Author:
DP Potaczek ， H Harb ， S Michel ， BA Alhamwe ， H Renz ， ...
2018-10-24 Review
Hangzhou Zheda Dixun Biological Gene Engineering Co., Ltd. Copyright HZKC Technical support 浙ICP備14005341號(hào) （浙）-非經(jīng)營性-2019-0050
Address: Rm.201-209, Bldg.2, No.568 Binkang Rd., Binjiang Dist. Tel: 0571-87968248-805 Website:baochunhua.cn
COPYRIGHT©2003-2024 baochunhua.cn CORPORATION. ALL RIGHTS RESERVED
Official WeChat