Sensitisation to minor cat allergen components is associated with type-2 biomarkers in young asthmatics DOI: 10.1111/cea.13135 Abstract: Background: Cat allergy is a major trigger of asthma worldwide. Molecular patterns of cat sensitisationvary between individuals, but their relationship to inflammation in asthmatics has not beenextensively studied. Methods: Patients with asthma (age 10?35 years; n=266) and IgE sensitisation to cat, dog or horse extract (ImmunoCAP), were analysed for IgE to the cat allergen components Fel d 1 (secretoglobin), Fel d 2 (serum albumin), Fel d 4 and Fel d 7 (lipocalins). Independent associations between IgE-antibody concentrations, and fraction of exhaled nitric oxide (FeNO), blood eosinophil (B-Eos) count, and total IgE were analysed by multiple linear regression after adjustment for possible confounders. Results: The level of IgE against Fel d 2 was independently related to FeNO (p=0.012) and total IgE (p<0.001), and IgE against Fel d 4 associated with Β-Eos count (p=0.009) and total IgE (p<0.001). IgE antibodies against Fel d 1 or cat extract did not independently relate to these inflammatory markers (p=0.23?0.51). Conclusions: Levels of IgE to lipocalin (Fel d 4) and serum albumin (Fel d 2), but not to secretoglobin (Fel d 1) or cat extract, were independently associated with type-2 biomarkers and total IgE in young asthmatics. First Author: Tsolakis N. Correspondence: Department of Women’s and Children’s Health, Uppsala University All Authors: Tsolakis N, Malinovschi A, Nordvall L, Mattsson L, Lidholm J, Pedroletti C, Janson C, Borres M.P, and Alving K